Cat. No：GM-C36651
Product：Insulin Receptor A(IRA) Reporter Cell Line
Cat. No：GM-C36651
Product：Insulin Receptor A(IRA) Reporter Cell Line
Cell Growth Medium：DMEM+10% FBS+1% P.S+4 μg/mL Blasticidin+0.75 μg/mL Puromycin
Cell Freezing Medium：90% FBS+10% DMSO
Assay Buffer：DMEM+1% FBS+1% P.S
There are two subtypes of INSR (insulin receptor), namely IR-A and IR-B, whose relative expression patterns are tissue-specific. Insulin transmits signals by binding to INSR (insulin receptor), which is a member of the single transmembrane receptor tyrosine kinase family. When Insulin binds to INSR, it leads to intracellular substrate phosphorylation, thereby activating downstream signaling pathways.
Jiman Biological Insulin Receptor A (IRA) Reporter Cell Line reports gene expression in cell lines. When Insulin binds to the Insulin Receptor A (IR-A) receptor on the cell surface, it activates downstream signaling pathways, thereby activating the expression of luciferase. The use of blocking antibodies can block the transmission of this signal. The Luciferase reading represents the activation of the signaling pathway, therefore this cell can be used for in vitro efficacy evaluation of insulin related drugs.
| INSR:insulin | ||
| Insulin Reporter Cell Line | H_INSR CHO-K1 Cell Line | H_INSR HEK-293 Cell Line |
| Anti-H_INSR hIgG1 Antibody(Valanafusp) | Anti-INSR hIgG1 Antibody(XPA.15.247.2.018) | |
Cat. No：GM-C36651
Product：Insulin Receptor A(IRA) Reporter Cell Line
Cell Growth Medium：DMEM+10% FBS+1% P.S+4 μg/mL Blasticidin+0.75 μg/mL Puromycin
Cell Freezing Medium：90% FBS+10% DMSO
Assay Buffer：DMEM+1% FBS+1% P.S
There are two subtypes of INSR (insulin receptor), namely IR-A and IR-B, whose relative expression patterns are tissue-specific. Insulin transmits signals by binding to INSR (insulin receptor), which is a member of the single transmembrane receptor tyrosine kinase family. When Insulin binds to INSR, it leads to intracellular substrate phosphorylation, thereby activating downstream signaling pathways.
Jiman Biological Insulin Receptor A (IRA) Reporter Cell Line reports gene expression in cell lines. When Insulin binds to the Insulin Receptor A (IR-A) receptor on the cell surface, it activates downstream signaling pathways, thereby activating the expression of luciferase. The use of blocking antibodies can block the transmission of this signal. The Luciferase reading represents the activation of the signaling pathway, therefore this cell can be used for in vitro efficacy evaluation of insulin related drugs.
| INSR:insulin | ||
| Insulin Reporter Cell Line | H_INSR CHO-K1 Cell Line | H_INSR HEK-293 Cell Line |
| Anti-H_INSR hIgG1 Antibody(Valanafusp) | Anti-INSR hIgG1 Antibody(XPA.15.247.2.018) | |
