Species Reactivity Human
Clone 80A8
Source/Isotype Human IgG1(K214R,D256E,L358M), Kappa
Application Flow cytometry
Specificity Detects GPRC5D
Gene GPRC5D
Other Names G-protein coupled receptor family C group 5 member D
Gene ID 55507 (Human)
Background GPRC5D (g protein-coupled receptor class C Group 5member D) is a g protein-coupled orphan receptor that belongs to the 7th transmembrane protein. Expression is limited in normal tissues, usually limited to hair follicles, but specifically high in MM cells. Studies have found that GPRC5D mRNA expression correlates with plasma cell burden and gene aberrations. GPRC5D activates multiple signaling pathways, including those for cell proliferation, survival, and migration, to promote the growth and proliferation of MM cells. GPRC5D has been shown to be expressed on the surface of myeloma cells independently of BCMA and has been identified as an alternative immunotherapy target antigen for this indication. Therefore, targeted therapy against GPRC5D has emerged as a new direction for MM treatment.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
