Cat. No：GM-C37605
Product：H_CALCR Reporter CHO-K1 Cell Line
Cat. No：GM-C37605
Product：H_CALCR Reporter CHO-K1 Cell Line
Cell Growth Medium：F12K+10% FBS+1% P.S+4 μg/mL Blasticidin+4 μg/mL Puromycin
Cell Freezing Medium：90% FBS+10% DMSO
Assay Buffer：F12K +1% FBS+1% P.S
Calcitonin Receptor (CalcR) is an important cell membrane receptor belonging to the G protein coupled receptor (GPCR) family. It has multiple transmembrane segments and can interact with different G proteins to activate downstream signaling pathways. The diversity of its structure enables it to bind to various ligands and regulate different physiological responses.
CalcR mainly binds to calcitonin and participates in regulating the balance of calcium in the body. Expressed in bones, kidneys, and central nervous system, it plays multiple physiological functions. The dysfunction of CALCR is associated with various diseases, such as osteoporosis, thyroid disease, and certain types of cancer. Therefore, CALCR and its signaling pathway have become potential therapeutic targets.
Jiman Biological's H_CalcR Reporter CHO-K1 Cell Line reporter gene cell line is a Luciferase reporter gene cell line constructed based on the cAMP signaling pathway. When Calcitonin salmon binds to CALCR, it activates the expression of luciferase through the cAMP signaling pathway. The Luciferase reading represents the activation effect of the signaling pathway, and therefore can be used for in vitro efficacy evaluation of Calcitonin salmon related drugs.
Cat. No：GM-C37605
Product：H_CALCR Reporter CHO-K1 Cell Line
Cell Growth Medium：F12K+10% FBS+1% P.S+4 μg/mL Blasticidin+4 μg/mL Puromycin
Cell Freezing Medium：90% FBS+10% DMSO
Assay Buffer：F12K +1% FBS+1% P.S
Calcitonin Receptor (CalcR) is an important cell membrane receptor belonging to the G protein coupled receptor (GPCR) family. It has multiple transmembrane segments and can interact with different G proteins to activate downstream signaling pathways. The diversity of its structure enables it to bind to various ligands and regulate different physiological responses.
CalcR mainly binds to calcitonin and participates in regulating the balance of calcium in the body. Expressed in bones, kidneys, and central nervous system, it plays multiple physiological functions. The dysfunction of CALCR is associated with various diseases, such as osteoporosis, thyroid disease, and certain types of cancer. Therefore, CALCR and its signaling pathway have become potential therapeutic targets.
Jiman Biological's H_CalcR Reporter CHO-K1 Cell Line reporter gene cell line is a Luciferase reporter gene cell line constructed based on the cAMP signaling pathway. When Calcitonin salmon binds to CALCR, it activates the expression of luciferase through the cAMP signaling pathway. The Luciferase reading represents the activation effect of the signaling pathway, and therefore can be used for in vitro efficacy evaluation of Calcitonin salmon related drugs.
