Cat.No：GM-87700AB
Product ：Anti-ACVR2B mIgG2a Antibody(Bimagrumab)
Cat.No：GM-87700AB
Product ：Anti-ACVR2B mIgG2a Antibody(Bimagrumab)
GM-87700AB-10 10 μg
GM-87700AB-100 100 μg
GM-87700AB-1000 1 mg
Species Reactivity Human
Clone Bimagrumab
Source/Isotype Monoclonal mouse IgG2a, κ
Application Bioactivity-ELISA
Specificity Detects ACVR2B
Gene ACVR2B
Other Names ACTRIIB, ActR-IIB, HTX4
Gene ID 93(human)
Background ACVR2B is an activin type 2 receptor.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. ACVR2B binds to activin and growth differentiation factor (GDF), which in turn activates type I receptors ansd activates downstream molecules. In addition, mutations in this gene may affect protein function in left and right axis formation and cardiovascular development, as well as reduce muscle mass and bone mass.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Cat.No：GM-87700AB
Product ：Anti-ACVR2B mIgG2a Antibody(Bimagrumab)
GM-87700AB-10 10 μg
GM-87700AB-100 100 μg
GM-87700AB-1000 1 mg
Species Reactivity Human
Clone Bimagrumab
Source/Isotype Monoclonal mouse IgG2a, κ
Application Bioactivity-ELISA
Specificity Detects ACVR2B
Gene ACVR2B
Other Names ACTRIIB, ActR-IIB, HTX4
Gene ID 93(human)
Background ACVR2B is an activin type 2 receptor.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. ACVR2B binds to activin and growth differentiation factor (GDF), which in turn activates type I receptors ansd activates downstream molecules. In addition, mutations in this gene may affect protein function in left and right axis formation and cardiovascular development, as well as reduce muscle mass and bone mass.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
