Cat. No：GM-C31367
Product：H_CCDC6-RET(V804M) BaF3 Cell Line
Cat. No：GM-C31367
Product：H_CCDC6-RET(V804M) BaF3 Cell Line
Cell Growth Medium：RPMI 1640+10% FBS+1% P.S+0.25 μg/mL Puromycin
Cell Culture Freezing Medium：90% FBS+10% DMSO
Assay Buffer：RPMI 1640+10% FBS+1% P.S
The CCDC6-RET kinase protein is a fusion protein comprised of the CCDC6 (Coiled-Coil Domain-Containing Protein 6) and RET (Rearranged during Transfection) kinase proteins. This protein undergoes mutations in certain tumor cells, leading to its activation and promoting tumor growth and metastasis. The CCDC6-RET kinase protein is commonly seen in tumors like lung cancer and thyroid cancer, making it a potential therapeutic target. Research indicates that inhibiting the activity of the CCDC6-RET kinase protein can effectively suppress tumor growth and spread, providing new avenues for cancer treatment. Several tyrosine kinase inhibitors (TKIs) targeting the CCDC6-RET fusion gene are available, such as Cabozantinib, Selpercatinib, and Pralsetinib.
BA/F3 cells are a type of IL-3-dependent precursor B cell, where certain protein kinases can substitute for IL-3 to promote the growth of Ba/F3 cells. By using inhibitors to counteract this effect, this can be utilized for research on kinase inhibitors.
| RET BAF3 | ||
| H_CCDC6-RET BaF3 Cell Line | H_CCDC6-RET(V804L) BaF3 Cell Line | H_KIF5B-RET BaF3 Cell Line |
| H_KIF5B-RET(G810A) BaF3 Cell Line | H_KIF5B-RET(G810C) BaF3 Cell Line | H_KIF5B-RET(G810R) BaF3 Cell Line |
| H_KIF5B-RET(G810S) BaF3 Cell Line | H_KIF5B-RET(L) BaF3 Cell Line | H_KIF5B-RET(L730I) BaF3 Cell Line |
| H_KIF5B-RET(L730V) BaF3 Cell Line | H_KIF5B-RET(M918T) BaF3 Cell Line | H_KIF5B-RET(S819A) BaF3 Cell Line |
| H_KIF5B-RET(S904F) BaF3 Cell Line | H_KIF5B-RET(T729-L730insL) BaF3 Cell Line | H_KIF5B-RET(V804E) BaF3 Cell Line |
| H_KIF5B-RET(V804L) BaF3 Cell Line | H_KIF5B-RET(V804M) BaF3 Cell Line | H_KIF5B-RET(V804M-G810R) BaF3 Cell Line |
| H_KIF5B-RET(V804M-G810S) BaF3 Cell Line | H_KIF5B-RET(Y806N) BaF3 Cell Line | H_NCOA4-RET BaF3 Cell Line |
Cat. No：GM-C31367
Product：H_CCDC6-RET(V804M) BaF3 Cell Line
Cell Growth Medium：RPMI 1640+10% FBS+1% P.S+0.25 μg/mL Puromycin
Cell Culture Freezing Medium：90% FBS+10% DMSO
Assay Buffer：RPMI 1640+10% FBS+1% P.S
The CCDC6-RET kinase protein is a fusion protein comprised of the CCDC6 (Coiled-Coil Domain-Containing Protein 6) and RET (Rearranged during Transfection) kinase proteins. This protein undergoes mutations in certain tumor cells, leading to its activation and promoting tumor growth and metastasis. The CCDC6-RET kinase protein is commonly seen in tumors like lung cancer and thyroid cancer, making it a potential therapeutic target. Research indicates that inhibiting the activity of the CCDC6-RET kinase protein can effectively suppress tumor growth and spread, providing new avenues for cancer treatment. Several tyrosine kinase inhibitors (TKIs) targeting the CCDC6-RET fusion gene are available, such as Cabozantinib, Selpercatinib, and Pralsetinib.
BA/F3 cells are a type of IL-3-dependent precursor B cell, where certain protein kinases can substitute for IL-3 to promote the growth of Ba/F3 cells. By using inhibitors to counteract this effect, this can be utilized for research on kinase inhibitors.
| RET BAF3 | ||
| H_CCDC6-RET BaF3 Cell Line | H_CCDC6-RET(V804L) BaF3 Cell Line | H_KIF5B-RET BaF3 Cell Line |
| H_KIF5B-RET(G810A) BaF3 Cell Line | H_KIF5B-RET(G810C) BaF3 Cell Line | H_KIF5B-RET(G810R) BaF3 Cell Line |
| H_KIF5B-RET(G810S) BaF3 Cell Line | H_KIF5B-RET(L) BaF3 Cell Line | H_KIF5B-RET(L730I) BaF3 Cell Line |
| H_KIF5B-RET(L730V) BaF3 Cell Line | H_KIF5B-RET(M918T) BaF3 Cell Line | H_KIF5B-RET(S819A) BaF3 Cell Line |
| H_KIF5B-RET(S904F) BaF3 Cell Line | H_KIF5B-RET(T729-L730insL) BaF3 Cell Line | H_KIF5B-RET(V804E) BaF3 Cell Line |
| H_KIF5B-RET(V804L) BaF3 Cell Line | H_KIF5B-RET(V804M) BaF3 Cell Line | H_KIF5B-RET(V804M-G810R) BaF3 Cell Line |
| H_KIF5B-RET(V804M-G810S) BaF3 Cell Line | H_KIF5B-RET(Y806N) BaF3 Cell Line | H_NCOA4-RET BaF3 Cell Line |
