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Current position:Product Center > Cell lines > Kinase > RET > H_KIF5B-RET(L730I) BaF3 Cell Line
H_KIF5B-RET(L730I) BaF3 Cell Line
Product Info

Cat. No:GM-C31372

Product:H_KIF5B-RET(L730I) BaF3 Cell Line

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Materials required

Cell Growth Medium:RPMI 1640+10% FBS+1% P.S+0.25 μg/mL Puromycin

Cell Freezing Medium:90% FBS+10% DMSO

Assay Buffer:RPMI 1640+10% FBS+1% P.S


Description

The KIF5B-RET fusion protein is produced by the fusion of the KIF5B (kinesin family member 5B) and RET (Rearranged during Transfection) genes. This fusion protein has been found in some tumors, particularly in lung cancer and thyroid cancer. The KIF5B-RET fusion protein possesses kinase activity, enabling it to activate cell signaling pathways that promote tumor growth and metastasis. Therefore, the KIF5B-RET fusion protein is regarded as a significant driver of tumors and a potential therapeutic target. BA/F3 cells are precursor B cells that depend on interleukin-3 (IL-3), and some protein kinases can replace IL-3 to enable dependent growth of Ba/F3 cells. This effect can be antagonized using inhibitors, thus allowing for research into kinase inhibitors.

Data
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Current Position:Product Center > Cell lines > Kinase > RET > H_KIF5B-RET(L730I) BaF3 Cell Line
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H_KIF5B-RET(L730I) BaF3 Cell Line
Product Info

Cat. No:GM-C31372

Product:H_KIF5B-RET(L730I) BaF3 Cell Line

产品配图.jpg



Materials required

Cell Growth Medium:RPMI 1640+10% FBS+1% P.S+0.25 μg/mL Puromycin

Cell Freezing Medium:90% FBS+10% DMSO

Assay Buffer:RPMI 1640+10% FBS+1% P.S


Description

The KIF5B-RET fusion protein is produced by the fusion of the KIF5B (kinesin family member 5B) and RET (Rearranged during Transfection) genes. This fusion protein has been found in some tumors, particularly in lung cancer and thyroid cancer. The KIF5B-RET fusion protein possesses kinase activity, enabling it to activate cell signaling pathways that promote tumor growth and metastasis. Therefore, the KIF5B-RET fusion protein is regarded as a significant driver of tumors and a potential therapeutic target. BA/F3 cells are precursor B cells that depend on interleukin-3 (IL-3), and some protein kinases can replace IL-3 to enable dependent growth of Ba/F3 cells. This effect can be antagonized using inhibitors, thus allowing for research into kinase inhibitors.

Data
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