Cat. No：GM-C31383
Product：H_KIF5B-RET(V804M-G810S) BaF3 Cell Line
Cat. No：GM-C31383
Product：H_KIF5B-RET(V804M-G810S) BaF3 Cell Line
Cell Growth Medium：RPMI 1640+10% FBS+1% P.S+0.25 μg/mL Puromycin
Cell Freezing Medium：90% FBS+10% DMSO
Assay Buffer：RPMI 1640+10% FBS+1% P.S
The KIF5B-RET fusion protein is a protein produced by the fusion of KIF5B (kinesin family member 5B) and the RET (Rearranged during Transfection) gene. This fusion protein has been found in several tumors, particularly lung cancer and thyroid cancer. The KIF5B-RET fusion protein possesses kinase activity, which can activate cell signaling pathways, promoting tumor growth and metastasis. Therefore, the KIF5B-RET fusion protein is considered an important driver of tumors and a potential therapeutic target. BA/F3 cells are a type of precursor B cell that depend on interleukin-3 (IL-3); however, some kinases can substitute for IL-3 to promote the growth of BA/F3 cells. By using inhibitors to antagonize this effect, this phenomenon can be utilized for research on kinase inhibitors.
| RET BAF3 | ||
| H_CCDC6-RET BaF3 Cell Line | H_CCDC6-RET(V804L) BaF3 Cell Line | H_CCDC6-RET(V804M) BaF3 Cell Line |
| H_KIF5B-RET BaF3 Cell Line | H_KIF5B-RET(G810A) BaF3 Cell Line | H_KIF5B-RET(G810C) BaF3 Cell Line |
| H_KIF5B-RET(G810R) BaF3 Cell Line | H_KIF5B-RET(G810S) BaF3 Cell Line | H_KIF5B-RET(L) BaF3 Cell Line |
| H_KIF5B-RET(L730I) BaF3 Cell Line | H_KIF5B-RET(L730V) BaF3 Cell Line | H_KIF5B-RET(M918T) BaF3 Cell Line |
| H_KIF5B-RET(S819A) BaF3 Cell Line | H_KIF5B-RET(S904F) BaF3 Cell Line | H_KIF5B-RET(T729-L730insL) BaF3 Cell Line |
| H_KIF5B-RET(V804E) BaF3 Cell Line | H_KIF5B-RET(V804L) BaF3 Cell Line | H_KIF5B-RET(V804M) BaF3 Cell Line |
| H_KIF5B-RET(V804M-G810R) BaF3 Cell Line | H_KIF5B-RET(Y806N) BaF3 Cell Line | H_NCOA4-RET BaF3 Cell Line |
Cat. No：GM-C31383
Product：H_KIF5B-RET(V804M-G810S) BaF3 Cell Line
Cell Growth Medium：RPMI 1640+10% FBS+1% P.S+0.25 μg/mL Puromycin
Cell Freezing Medium：90% FBS+10% DMSO
Assay Buffer：RPMI 1640+10% FBS+1% P.S
The KIF5B-RET fusion protein is a protein produced by the fusion of KIF5B (kinesin family member 5B) and the RET (Rearranged during Transfection) gene. This fusion protein has been found in several tumors, particularly lung cancer and thyroid cancer. The KIF5B-RET fusion protein possesses kinase activity, which can activate cell signaling pathways, promoting tumor growth and metastasis. Therefore, the KIF5B-RET fusion protein is considered an important driver of tumors and a potential therapeutic target. BA/F3 cells are a type of precursor B cell that depend on interleukin-3 (IL-3); however, some kinases can substitute for IL-3 to promote the growth of BA/F3 cells. By using inhibitors to antagonize this effect, this phenomenon can be utilized for research on kinase inhibitors.
| RET BAF3 | ||
| H_CCDC6-RET BaF3 Cell Line | H_CCDC6-RET(V804L) BaF3 Cell Line | H_CCDC6-RET(V804M) BaF3 Cell Line |
| H_KIF5B-RET BaF3 Cell Line | H_KIF5B-RET(G810A) BaF3 Cell Line | H_KIF5B-RET(G810C) BaF3 Cell Line |
| H_KIF5B-RET(G810R) BaF3 Cell Line | H_KIF5B-RET(G810S) BaF3 Cell Line | H_KIF5B-RET(L) BaF3 Cell Line |
| H_KIF5B-RET(L730I) BaF3 Cell Line | H_KIF5B-RET(L730V) BaF3 Cell Line | H_KIF5B-RET(M918T) BaF3 Cell Line |
| H_KIF5B-RET(S819A) BaF3 Cell Line | H_KIF5B-RET(S904F) BaF3 Cell Line | H_KIF5B-RET(T729-L730insL) BaF3 Cell Line |
| H_KIF5B-RET(V804E) BaF3 Cell Line | H_KIF5B-RET(V804L) BaF3 Cell Line | H_KIF5B-RET(V804M) BaF3 Cell Line |
| H_KIF5B-RET(V804M-G810R) BaF3 Cell Line | H_KIF5B-RET(Y806N) BaF3 Cell Line | H_NCOA4-RET BaF3 Cell Line |
