News
Current position:Product Center > Cell lines > Kinase > RET > H_KIF5B-RET(G810S) BaF3 Cell Line
H_KIF5B-RET(G810S) BaF3 Cell Line
Product Info

Cat. No:GM-C31371

Product:H_KIF5B-RET(G810S) BaF3 Cell Line

产品配图.jpg




Materials required

Cell Growth Medium:RPMI 1640+10% FBS+1% P.S+0.25 μg/mL Puromycin

Cell Freezing Medium:90% FBS+10% DMSO

Assay Buffer:RPMI 1640+10% FBS+1% P.S

Description

The KIF5B-RET fusion protein is produced by the fusion of the KIF5B (kinesin family member 5B) and RET (Rearranged during Transfection) genes. This fusion protein has been found in some tumors, particularly in lung cancer and thyroid cancer. The KIF5B-RET fusion protein possesses kinase activity, enabling it to activate cell signaling pathways that promote tumor growth and metastasis. Therefore, the KIF5B-RET fusion protein is regarded as a significant driver of tumors and a potential therapeutic target. BA/F3 cells are precursor B cells that depend on interleukin-3 (IL-3), and some protein kinases can replace IL-3 to enable dependent growth of Ba/F3 cells. This effect can be antagonized using inhibitors, thus allowing for research into kinase inhibitors.

Data
Related Products
RET BAF3
H_CCDC6-RET BaF3 Cell LineH_CCDC6-RET(V804L) BaF3 Cell LineH_CCDC6-RET(V804M) BaF3 Cell Line
H_KIF5B-RET BaF3 Cell LineH_KIF5B-RET(G810A) BaF3 Cell LineH_KIF5B-RET(G810C) BaF3 Cell Line
H_KIF5B-RET(G810R) BaF3 Cell LineH_KIF5B-RET(L) BaF3 Cell LineH_KIF5B-RET(L730I) BaF3 Cell Line
H_KIF5B-RET(L730V) BaF3 Cell LineH_KIF5B-RET(M918T) BaF3 Cell LineH_KIF5B-RET(S819A) BaF3 Cell Line
H_KIF5B-RET(S904F) BaF3 Cell LineH_KIF5B-RET(T729-L730insL) BaF3 Cell LineH_KIF5B-RET(V804E) BaF3 Cell Line
H_KIF5B-RET(V804L) BaF3 Cell LineH_KIF5B-RET(V804M) BaF3 Cell LineH_KIF5B-RET(V804M-G810R) BaF3 Cell Line
H_KIF5B-RET(V804M-G810S) BaF3 Cell LineH_KIF5B-RET(Y806N) BaF3 Cell LineH_NCOA4-RET BaF3 Cell Line


Current Position:Product Center > Cell lines > Kinase > RET > H_KIF5B-RET(G810S) BaF3 Cell Line
classify
H_KIF5B-RET(G810S) BaF3 Cell Line
Product Info

Cat. No:GM-C31371

Product:H_KIF5B-RET(G810S) BaF3 Cell Line

产品配图.jpg




Materials required

Cell Growth Medium:RPMI 1640+10% FBS+1% P.S+0.25 μg/mL Puromycin

Cell Freezing Medium:90% FBS+10% DMSO

Assay Buffer:RPMI 1640+10% FBS+1% P.S

Description

The KIF5B-RET fusion protein is produced by the fusion of the KIF5B (kinesin family member 5B) and RET (Rearranged during Transfection) genes. This fusion protein has been found in some tumors, particularly in lung cancer and thyroid cancer. The KIF5B-RET fusion protein possesses kinase activity, enabling it to activate cell signaling pathways that promote tumor growth and metastasis. Therefore, the KIF5B-RET fusion protein is regarded as a significant driver of tumors and a potential therapeutic target. BA/F3 cells are precursor B cells that depend on interleukin-3 (IL-3), and some protein kinases can replace IL-3 to enable dependent growth of Ba/F3 cells. This effect can be antagonized using inhibitors, thus allowing for research into kinase inhibitors.

Data
Related Products
RET BAF3
H_CCDC6-RET BaF3 Cell LineH_CCDC6-RET(V804L) BaF3 Cell LineH_CCDC6-RET(V804M) BaF3 Cell Line
H_KIF5B-RET BaF3 Cell LineH_KIF5B-RET(G810A) BaF3 Cell LineH_KIF5B-RET(G810C) BaF3 Cell Line
H_KIF5B-RET(G810R) BaF3 Cell LineH_KIF5B-RET(L) BaF3 Cell LineH_KIF5B-RET(L730I) BaF3 Cell Line
H_KIF5B-RET(L730V) BaF3 Cell LineH_KIF5B-RET(M918T) BaF3 Cell LineH_KIF5B-RET(S819A) BaF3 Cell Line
H_KIF5B-RET(S904F) BaF3 Cell LineH_KIF5B-RET(T729-L730insL) BaF3 Cell LineH_KIF5B-RET(V804E) BaF3 Cell Line
H_KIF5B-RET(V804L) BaF3 Cell LineH_KIF5B-RET(V804M) BaF3 Cell LineH_KIF5B-RET(V804M-G810R) BaF3 Cell Line
H_KIF5B-RET(V804M-G810S) BaF3 Cell LineH_KIF5B-RET(Y806N) BaF3 Cell LineH_NCOA4-RET BaF3 Cell Line


Tel: 400-627-9288
Message consultation
reset
submit
Service
WhatApp
Phone
Message
Message consultation
reset
submit