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Current position:Product Center > Antibodies > Biosimilar Antibodies > Anti-H_GUCY2C hIgG1 Antibody(Indusatumab)
Anti-H_GUCY2C hIgG1 Antibody(Indusatumab)
Product info

Cat.No:GM-28860AB

Product:Anti-H_GUCY2C hIgG1 Antibody(Indusatumab)





Cat. No. & Size

GM-28860AB-10          10 μg

GM-28860AB-100        100 μg

GM-28860AB-1000      1mg


Description️

Species Reactivity      Human

Clone                           Indusatumab

Source/Isotype           Monoclonal Human IgG1, κ

Application                 Flow Cytometry

Specificity                   Detects GUCY2C

Gene                            GUCY2C

Other Names              DIAR6, GC-C, GUC2C, MECIL, MUCIL, STAR

Gene ID                       2984(human)

Background                Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an enzyme that in humans is encoded by the GUCY2C gene. Guanylyl cyclase is an enzyme found in the luminal aspect of intestinal epithelium and dopamine neurons in the brain.The receptor has an extracellular ligand-binding domain, a single transmembrane region, a region with sequence similar to that of protein kinases, and a C-terminal guanylate cyclase domain. Tyrosine kinase activity mediates the GC-C signaling pathway within the cell. GUCY2C is a key receptor for heat-stable enterotoxins that are responsible for acute secretory diarrhea. Heat-stable enterotoxins are produced by pathogens such as Escherichia coli. Knockout mice deficient in the GUCY2C gene do not show secretory diarrhea on infection with E. coli, though they do with cholera toxin. This demonstrates the specificity of the GUCY2C receptor.

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Phosphate-buffered solution, pH 7.2.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay



Data

/ueditor/image/20240515/1715761621471391/59edc711410b1f55f2c44ec2958499fa.png


Current position:Product Center > -- > Anti-H_GUCY2C hIgG1 Antibody(Indusatumab)
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Anti-H_GUCY2C hIgG1 Antibody(Indusatumab)
Product info

Cat.No:GM-28860AB

Product:Anti-H_GUCY2C hIgG1 Antibody(Indusatumab)





Cat. No. & Size

GM-28860AB-10          10 μg

GM-28860AB-100        100 μg

GM-28860AB-1000      1mg


Description️

Species Reactivity      Human

Clone                           Indusatumab

Source/Isotype           Monoclonal Human IgG1, κ

Application                 Flow Cytometry

Specificity                   Detects GUCY2C

Gene                            GUCY2C

Other Names              DIAR6, GC-C, GUC2C, MECIL, MUCIL, STAR

Gene ID                       2984(human)

Background                Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an enzyme that in humans is encoded by the GUCY2C gene. Guanylyl cyclase is an enzyme found in the luminal aspect of intestinal epithelium and dopamine neurons in the brain.The receptor has an extracellular ligand-binding domain, a single transmembrane region, a region with sequence similar to that of protein kinases, and a C-terminal guanylate cyclase domain. Tyrosine kinase activity mediates the GC-C signaling pathway within the cell. GUCY2C is a key receptor for heat-stable enterotoxins that are responsible for acute secretory diarrhea. Heat-stable enterotoxins are produced by pathogens such as Escherichia coli. Knockout mice deficient in the GUCY2C gene do not show secretory diarrhea on infection with E. coli, though they do with cholera toxin. This demonstrates the specificity of the GUCY2C receptor.

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Phosphate-buffered solution, pH 7.2.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay



Data

/ueditor/image/20240515/1715761621471391/59edc711410b1f55f2c44ec2958499fa.png


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