Cat. No：GM-C27577
Product：H_TLR3 Reporter 293 Cell Line
Cat. No：GM-C27577
Product：H_TLR3 Reporter 293 Cell Line
Cell Growth Medium：EMEM+10% FBS+1% P.S+1.5 μg/mL Puromycin+3 μg/mL Blasticidin
Cell Freezing Medium：90% FBS+10% DMSO
Assay Buffer：EMEM+1% FBS+1% P.S
Toll-like receptors (TLRs) are an important class of proteins involved in the innate immune response, serving as a bridge between innate and adaptive immunity. TLR3, a pattern recognition receptor mainly expressed in the endoplasmic reticulum-lysosome, detects viral infections by binding to dsRNA. In addition to virus-induced dsRNA, endogenous dsRNA released during tissue damage can also activate TLR3. Synthetic dsRNA like Poly(I:C), Poly(A:U), and their variants can also activate TLR3. Upon activation, TLR3 translocates from the endoplasmic reticulum to the Golgi apparatus and lysosomes, where it interacts with the main protein MyD88 in the signaling pathway to activate downstream signals.
The H_TLR3 Reporter 293 Cell Line from Jinan Biology is a reporter gene cell line constructed based on the TLR3 signaling pathway. This cell line stably expresses the TLR3 gene and the Luciferase reporter gene, making it suitable for evaluating the in vitro activation effects of dsRNA acting on TLR3.
Cat. No：GM-C27577
Product：H_TLR3 Reporter 293 Cell Line
Cell Growth Medium：EMEM+10% FBS+1% P.S+1.5 μg/mL Puromycin+3 μg/mL Blasticidin
Cell Freezing Medium：90% FBS+10% DMSO
Assay Buffer：EMEM+1% FBS+1% P.S
Toll-like receptors (TLRs) are an important class of proteins involved in the innate immune response, serving as a bridge between innate and adaptive immunity. TLR3, a pattern recognition receptor mainly expressed in the endoplasmic reticulum-lysosome, detects viral infections by binding to dsRNA. In addition to virus-induced dsRNA, endogenous dsRNA released during tissue damage can also activate TLR3. Synthetic dsRNA like Poly(I:C), Poly(A:U), and their variants can also activate TLR3. Upon activation, TLR3 translocates from the endoplasmic reticulum to the Golgi apparatus and lysosomes, where it interacts with the main protein MyD88 in the signaling pathway to activate downstream signals.
The H_TLR3 Reporter 293 Cell Line from Jinan Biology is a reporter gene cell line constructed based on the TLR3 signaling pathway. This cell line stably expresses the TLR3 gene and the Luciferase reporter gene, making it suitable for evaluating the in vitro activation effects of dsRNA acting on TLR3.
