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Lentivirus

Cell Line Development

Protein Expression

Plasmid DNA Preparation Services

Adeno-associated Virus

Cell-based Assay

Antibody Services

Reporter Gene Detection Services

Plasmid

Stock Plasmid Reporter Plasmid Autophagy Fluorescent Single-Tag Plasmid Empty Vector Cell Tracking Plasmid iPS-Related Plasmids

Cell lines

Cytokines Immune checkpoints GPCR CLDN TAA Kinase TLR NK Antibody function Immunotherapy target In vivo imaging TNF LILR WNT Others Reference cells Antibody-related immune Recombinase Product integrin metabolism

Molecular Reference Standards

Reporter gene detection-related reagents

GMOne-Step GMOne-Step 2.0 GMBright One-Step GMSteady One-Step Dual Luciferase Reporter Gene Assay Kit D-Luciferin

Lentivirus

Overexpression Lentivirus Reporter Lentivirus In Vivo Imaging Lentivirus iPS-Related Lentivirus Immortalization Lentivirus Autophagy Lentivirus Cre Lentivirus Fluorescent Control Lentivirus

Proteins

Cytokines TAA Immune checkpoints Immunotherapy target GPCR TNF Kinase Others Antibody-related

Pseudovirus control material

Coronavirus-Like Pseudovirus Influenza-Like Pseudovirus Parainfluenza-Like Pseudovirus Respiratory Syncytial Virus-Like Pseudovirus Rhinovirus-Like Pseudovirus Human Metapneumovirus-Like Pseudovirus Monkeypox-Like Pseudovirus

Reagents related to cell function detection and analysis

GMTiter TM Luminescent Cell Viability Assay Cell Counting kit-8

Adeno-Associated Virus (AAV)

Optogenetics Chemical Genetics Calcium Imaging Cre Recombinase Standard Control Vectors

Antibodies

In Vivo MAb Antibodies ADC Antibody Loading Controls Antibodies & Tag Antibodies Biosimilar Antibodies Other Antibodies

Pseudovirus

SARS-CoV-2 pseudovirus Rabies Pseudovirus SARS Pseudovirus Influenza pseudovirus MERS pseudovirus HIV-1 Pseudovirus

Genoagent (Brand name of reagents)

lentiviral-packaging-tool Transfection Reagent Mycoplasma Removal Reagent Antibiotic Gene Knockout Kit Polybrene Switch-On Reagent Staphylococcal Enterotoxin E

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Current position：News > News

News

Could GDF15 Become the Next Super Target After PD-1 and GLP-1?

A recent Nature Aging study reveals that senescent tumor-adjacent epithelial cells secrete GDF15, driving colorectal cancer progression via a metabolic–epigenetic feedback loop. This expands GDF15’s role beyond tumor cells to its influence on the surrounding microenvironment.

Emerging as a hub connecting tumor growth, immune evasion, and systemic metabolism, GDF15 is a promising target across oncology, cancer cachexia, obesity, and metabolic diseases. Monoclonal antibodies like Ponsegromab and Visugromab are showing encouraging results in early clinical trials.

ADCC, ADCP, and CDC: Antibody Structure and Class Considerations

Antibodies have evolved into versatile therapeutic platforms, capable of not only targeting disease cells but also activating the immune system through ADCC, ADCP, and CDC. Advances in Fc engineering—such as glycoengineering, targeted mutations, and FcRn optimization—are now enhancing antibody potency, selectivity, and half-life, unlocking new opportunities in oncology, autoimmune disorders, and infectious diseases.

BCMA Drives Accelerated Expansion into the Autoimmune Therapeutics Field

BCMA, a well-established target in blood cancers, is now expanding its impact into autoimmune diseases. Leveraging its highly specific expression and favorable safety profile, BCMA is at the forefront of innovative therapies, including CAR-T cells, bispecific and trispecific antibodies, and antibody-drug conjugates.

Recent collaborations and rapid clinical advancements highlight BCMA as a key focus for next-generation immune-targeted treatments. Learn how this promising target is reshaping the future of immunotherapy and opening new possibilities for patients worldwide.

Toll-Like Receptors: Key Components of Innate Immunity

Toll-Like Receptors (TLRs) are emerging as one of the most promising frontiers in immunotherapy.

With major licensing deals and expanding clinical applications, TLR-targeting drugs are gaining rapid momentum. Their central role in innate immunity—driving antiviral, inflammatory, and vaccine responses—makes them powerful targets for next-generation therapies.

From cancer to infectious diseases, the commercial and scientific potential is growing fast.

Amylin’s Emerging Role in Next-Generation Weight-Loss and Metabolic Therapies

Amylin is rapidly emerging as the most competitive next-generation target beyond GLP-1 in the global obesity-drug market. The high-stakes bidding for Metsera underscores growing industry confidence in long-acting amylin analogs such as MET-233i, which offers once-monthly dosing and strong synergy with GLP-1 therapies. Compared with GLP-1 alone, amylin provides advantages in satiety, metabolic regulation, and muscle preservation—strengthening its value in future weight-loss strategies.

Pharma leaders including Novo Nordisk, Eli Lilly, Pfizer, Roche, and AbbVie are accelerating investment in amylin monotherapies and multi-target combinations, supported by promising early clinical results. As the field shifts into the post–GLP-1 era, amylin is positioned to become a core commercial driver of next-generation metabolic therapies.

TfR1: Linking Iron Metabolism, Cancer, and Neurological Disorders

In 2025, a $12B acquisition put TfR1 in the spotlight, signaling huge potential in rare diseases, cancer, and neurological disorders.

Across multiple cutting-edge programs, TfR1 is opening doors to transformative therapies that could redefine patient care.

Accelerating Development of FOLR1 Target to Advance Multidimensional Cancer Therapy

Folate receptor alpha (FRα, FOLR1) is rapidly becoming one of the hottest targets in tumor therapy. With multiple antibody–drug conjugates (ADCs) now entering Phase III trials from global leaders like Eli Lilly and AstraZeneca, and emerging players such as Bio Thera and ProTarget Bio joining the race, competition around this target is intensifying.

From Elahere’s FDA approval to a new generation of FRα-directed ADCs, monoclonal antibodies, CAR-T therapies, and vaccines, the field is shifting from concept validation to clinical reality.

Dive into the full analysis to see how FRα is redefining the landscape of epithelial tumor treatment — and why it’s drawing worldwide attention from oncology innovators.

PD-1 × IL-2: A Combined Approach to Redefining Tumor Immunotherapy Strategies

While PD-1 inhibitors have transformed cancer treatment, their limits are becoming clear — and a new wave of innovation is rising. Cytokine engineering and PD-1 × IL-2 fusion therapies are redefining how we think about precision immune activation.

As PD-1 inhibitors reach their limits, the next frontier lies in cytokine engineering. Both Roche and Innovent Biologics are pursuing the PD-1 × IL-2v fusion strategy — yet with fundamentally different design philosophies.

TSHR: The Core Target in Thyroid Metabolic Regulation and Disease Therapy

The thyroid-stimulating hormone receptor (TSHR) is emerging as a key target in next-generation thyroid and autoimmune disease treatments. Once limited to hormone regulation, TSHR therapies now combine endocrine and immune pathways for greater precision and efficacy. With growing research and industry momentum, TSHR is shaping the future of smarter, more targeted thyroid therapies.

GM-C41979 Dual-Receptor Reporter Cell Line for PD-1–IL-2v Evaluation

Genomeditech has published a white paper on the GM-C41979 Dual-Receptor Reporter Cell Line, detailing its design, validation, and application for PD-1–IL-2v fusion protein evaluation. The report showcases how GM-C41979 integrates PD-1 and IL-2R signaling to provide a high-sensitivity, PD-1-dependent assay system. This publication demonstrates Genomeditech’s commitment to advancing reliable analytical tools for next-generation immuno-oncology drug development.

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News

Could GDF15 Become the Next Super Target After PD-1 and GLP-1?

A recent Nature Aging study reveals that senescent tumor-adjacent epithelial cells secrete GDF15, driving colorectal cancer progression via a metabolic–epigenetic feedback loop. This expands GDF15’s role beyond tumor cells to its influence on the surrounding microenvironment.

Emerging as a hub connecting tumor growth, immune evasion, and systemic metabolism, GDF15 is a promising target across oncology, cancer cachexia, obesity, and metabolic diseases. Monoclonal antibodies like Ponsegromab and Visugromab are showing encouraging results in early clinical trials.

ADCC, ADCP, and CDC: Antibody Structure and Class Considerations

Antibodies have evolved into versatile therapeutic platforms, capable of not only targeting disease cells but also activating the immune system through ADCC, ADCP, and CDC. Advances in Fc engineering—such as glycoengineering, targeted mutations, and FcRn optimization—are now enhancing antibody potency, selectivity, and half-life, unlocking new opportunities in oncology, autoimmune disorders, and infectious diseases.

BCMA Drives Accelerated Expansion into the Autoimmune Therapeutics Field

BCMA, a well-established target in blood cancers, is now expanding its impact into autoimmune diseases. Leveraging its highly specific expression and favorable safety profile, BCMA is at the forefront of innovative therapies, including CAR-T cells, bispecific and trispecific antibodies, and antibody-drug conjugates.

Recent collaborations and rapid clinical advancements highlight BCMA as a key focus for next-generation immune-targeted treatments. Learn how this promising target is reshaping the future of immunotherapy and opening new possibilities for patients worldwide.

Toll-Like Receptors: Key Components of Innate Immunity

Toll-Like Receptors (TLRs) are emerging as one of the most promising frontiers in immunotherapy.

With major licensing deals and expanding clinical applications, TLR-targeting drugs are gaining rapid momentum. Their central role in innate immunity—driving antiviral, inflammatory, and vaccine responses—makes them powerful targets for next-generation therapies.

From cancer to infectious diseases, the commercial and scientific potential is growing fast.

Amylin’s Emerging Role in Next-Generation Weight-Loss and Metabolic Therapies

Amylin is rapidly emerging as the most competitive next-generation target beyond GLP-1 in the global obesity-drug market. The high-stakes bidding for Metsera underscores growing industry confidence in long-acting amylin analogs such as MET-233i, which offers once-monthly dosing and strong synergy with GLP-1 therapies. Compared with GLP-1 alone, amylin provides advantages in satiety, metabolic regulation, and muscle preservation—strengthening its value in future weight-loss strategies.

Pharma leaders including Novo Nordisk, Eli Lilly, Pfizer, Roche, and AbbVie are accelerating investment in amylin monotherapies and multi-target combinations, supported by promising early clinical results. As the field shifts into the post–GLP-1 era, amylin is positioned to become a core commercial driver of next-generation metabolic therapies.

TfR1: Linking Iron Metabolism, Cancer, and Neurological Disorders

In 2025, a $12B acquisition put TfR1 in the spotlight, signaling huge potential in rare diseases, cancer, and neurological disorders.

Across multiple cutting-edge programs, TfR1 is opening doors to transformative therapies that could redefine patient care.

Accelerating Development of FOLR1 Target to Advance Multidimensional Cancer Therapy

Folate receptor alpha (FRα, FOLR1) is rapidly becoming one of the hottest targets in tumor therapy. With multiple antibody–drug conjugates (ADCs) now entering Phase III trials from global leaders like Eli Lilly and AstraZeneca, and emerging players such as Bio Thera and ProTarget Bio joining the race, competition around this target is intensifying.

From Elahere’s FDA approval to a new generation of FRα-directed ADCs, monoclonal antibodies, CAR-T therapies, and vaccines, the field is shifting from concept validation to clinical reality.

Dive into the full analysis to see how FRα is redefining the landscape of epithelial tumor treatment — and why it’s drawing worldwide attention from oncology innovators.

PD-1 × IL-2: A Combined Approach to Redefining Tumor Immunotherapy Strategies

While PD-1 inhibitors have transformed cancer treatment, their limits are becoming clear — and a new wave of innovation is rising. Cytokine engineering and PD-1 × IL-2 fusion therapies are redefining how we think about precision immune activation.

As PD-1 inhibitors reach their limits, the next frontier lies in cytokine engineering. Both Roche and Innovent Biologics are pursuing the PD-1 × IL-2v fusion strategy — yet with fundamentally different design philosophies.

TSHR: The Core Target in Thyroid Metabolic Regulation and Disease Therapy

The thyroid-stimulating hormone receptor (TSHR) is emerging as a key target in next-generation thyroid and autoimmune disease treatments. Once limited to hormone regulation, TSHR therapies now combine endocrine and immune pathways for greater precision and efficacy. With growing research and industry momentum, TSHR is shaping the future of smarter, more targeted thyroid therapies.

GM-C41979 Dual-Receptor Reporter Cell Line for PD-1–IL-2v Evaluation

Genomeditech has published a white paper on the GM-C41979 Dual-Receptor Reporter Cell Line, detailing its design, validation, and application for PD-1–IL-2v fusion protein evaluation. The report showcases how GM-C41979 integrates PD-1 and IL-2R signaling to provide a high-sensitivity, PD-1-dependent assay system. This publication demonstrates Genomeditech’s commitment to advancing reliable analytical tools for next-generation immuno-oncology drug development.

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