CDH17 (Cadherin 17), also known as Liver-Intestine Cadherin (LI-cadherin), is a member of the cadherin superfamily and belongs to the atypical subtype of classical cadherins. The protein encoded by the CDH17 gene is primarily expressed in digestive system tissues such as the liver and small intestine. It is a transmembrane glycoprotein with seven extracellular calcium-binding domains (EC domains) but lacks the intracellular signaling domain typical of classical cadherins. CDH17 mediates calcium-dependent homophilic cell adhesion, playing a role in maintaining cell-cell connections and tissue structure. CDH17 is highly expressed in certain cancers, such as gastric cancer and colorectal cancer, and is associated with tumor invasiveness and metastatic potential. Therefore, it is considered a potential biomarker and therapeutic target for gastrointestinal tumors.
Genomeditech provides resources related to the CDH17 target, including overexpression cell lines, proteins, and antibodies, which can support the activity validation of CDH17-targeting antibodies. These tools will help researchers better evaluate and optimize the development of CDH17-related drugs, advancing their application in cancer immunotherapy.
