KRAS is a gene that encodes a small GTPase and is a critical member of the RAS family. As a proto-oncogene, KRAS plays an essential role in various cellular signal transduction pathways, regulating cell growth, differentiation, and survival. Mutations in KRAS are directly involved in the development and progression of multiple human cancers, making it a key driver gene in tumorigenesis.
Ba/F3 cells are a cell line derived from murine interleukin-3 (IL-3)-dependent pre-B cells that require IL-3 for survival and proliferation. When mutant KRAS genes are introduced, these cells become independent of IL-3 and start proliferating through KRAS-mediated signaling pathways. As a result, KRAS Ba/F3 cells serve as a classic tool to validate the oncogenic activity of KRAS mutations and are also widely used for screening KRAS inhibitors.
Genomeditech provides Ba/F3 cell lines targeting KRAS and other genes, supporting the screening, activity validation, and in vitro efficacy studies of KRAS inhibitors.
