| Species Reactivity | Human |
| Clone | CN40 |
| Source/Isotype | Human IgG1(REEM, K447del), Lambda2 |
| Application | / |
| Target | Detects CALCR |
| Gene | CALCR |
| Other Names | CRT, CT-R, CTR, CTR1 |
| Gene ID | 799 (Human) |
| Background | The CALCR gene encodes a calcitonin high-affinity receptor belonging to the g-protein-coupled receptor family and is located on human chromosome 7(7q21.3) , which is associated with a calcitonin receptor, it plays a central role in bone metabolism, tumorigenesis and neural regulation by regulating calcium homeostasis, inhibiting osteoclast activity and participating in adenylyl cyclase signaling pathway. Non-synonymous single-nucleotide polymorphism affects protein stability and may be used as a biomarker The techniques of immunohistochemistry, CRISPR knockout, lentiviral overexpression and bioinformatics were used in this study, to explore its potential in cancer treatment, bone healing (and autoimmune diseases, a number of clinical trials have verified the safety and effectiveness of its targeted drugs, providing key molecular targets for precision medicine. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
| Species Reactivity | Human |
| Clone | CN40 |
| Source/Isotype | Human IgG1(REEM, K447del), Lambda2 |
| Application | / |
| Target | Detects CALCR |
| Gene | CALCR |
| Other Names | CRT, CT-R, CTR, CTR1 |
| Gene ID | 799 (Human) |
| Background | The CALCR gene encodes a calcitonin high-affinity receptor belonging to the g-protein-coupled receptor family and is located on human chromosome 7(7q21.3) , which is associated with a calcitonin receptor, it plays a central role in bone metabolism, tumorigenesis and neural regulation by regulating calcium homeostasis, inhibiting osteoclast activity and participating in adenylyl cyclase signaling pathway. Non-synonymous single-nucleotide polymorphism affects protein stability and may be used as a biomarker The techniques of immunohistochemistry, CRISPR knockout, lentiviral overexpression and bioinformatics were used in this study, to explore its potential in cancer treatment, bone healing (and autoimmune diseases, a number of clinical trials have verified the safety and effectiveness of its targeted drugs, providing key molecular targets for precision medicine. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
