Cat. No：GM-58774AB

Product：Anti-ALPPL2 hIgG1 antibody(SGN-ALPV)

GM-58774AB-10          10 μg

GM-58774AB-100        100 μg

GM-58774AB-1000      1mg

Species Reactivity      Human; Cynomolgus

Clone                           SGN-ALPV

Source/Isotype           Monoclonal Human IgG1 /κ

Application                 Flow Cytometry

Specificity                   Detects ALPPL2; ALPP

Gene                            ALPPL2; ALPP

Other Names              ALPPL, ALPPL2, GCAP,ALP, ALPI, IAP, PALP, PLAP, PLAP-1

Gene ID                       ALPPL2: 251(human);ALPP: 250(human)、102133045(Cynomolgus)

Background                Alkaline phosphatase, placental type also known as placental alkaline phosphatase (PLAP) is an allosteric enzyme that in humans is encoded by the ALPP gene. PLAP is a tumor marker, especially in seminoma and ovarian cancer. There are at least four distinct but related alkaline phosphatases: intestinal (ALPI), placental (this enzyme), placental-like (ALPPL2), and liver/bone/kidney (ALPL) (tissue-nonspecific). The first three are located together on chromosome 2, whereas the tissue-nonspecific form is located on chromosome 1. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. Alkaline phosphatase, placental type is a membrane-bound glycosylated dimeric enzyme, also referred to as the heat-stable form, that is expressed primarily in the placenta, although it is closely related to the intestinal form of the enzyme as well as to the placental-like form.

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Phosphate-buffered solution, pH 7.2.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay