|
Species Reactivity |
Human |
|
Clone |
7F4 |
|
Source/Isotype |
Human IgG1(KEEM), Kappa |
|
Application |
Bioactivity-ELISA |
|
Target |
Detects ASGR1 |
|
Gene |
ASGR1 |
|
Other Names |
ASGP-R 1, ASGPR 1, Hepatic lectin H1, HL-1 |
|
Gene ID |
432 (Human) |
|
Background |
ASGR1 is a hepatocyte-expressed transmembrane glycoprotein that forms part of the ASGPR complex. It binds desialylated glycoproteins with terminal galactose or GalNAc, mediating endocytosis and clearance to maintain hepatic protein turnover. Structurally, it has a short cytoplasmic tail, a single transmembrane domain, and an extracellular lectin-like domain, working with ASGR2 for high-affinity binding. ASGR1 mainly drives clathrin-mediated endocytosis, routing ligands to endosomes/lysosomes. Beyond clearance, it influences signaling related to hepatic metabolism, inflammation, and receptor recycling, potentially affecting ubiquitination and recycling pathways and intersecting lipid/carbohydrate metabolism in hepatocytes. Dysregulation may impact plasma protein clearance and liver disease, making ASGPR a target for hepatic delivery and therapy. |
|
Storage |
Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
|
Formulation |
Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
|
Endotoxin |
< 1 EU/mg, determined by LAL gel clotting assay
|
