Species Reactivity      Human

Clone                           hMAB-A(2I.2)

Source/Isotype           Mouse IgG2a, Kappa

Application                 Flow cytometry

Specificity                   Detects ADAM9

Gene                            ADAM9

Other Names              KIAA0021, MCMP, MDC9, MLTNG

Gene ID                       8754 (Human)

Background                Adam9(a Disintegrin and Metalloprotease 9) , a multifunctional transmembrane protein in the Adam family, is localized on the human genome 8p11.22, encoding a multidomain type I transmembrane protein, which is a key component of the Adam family, it is widely expressed in monocytes, macrophages and a variety of tumor cells, but limited in normal tissues. Adam9 Cleaves Tek, KDR and other proteins through its metalloproteinase domain, and participates in tumorigenesis and angiogenesis. At the same time, Adam9 regulates cell movement through integrin interaction, affecting cell adhesion, migration and signal transduction. In addition, Adam9 may also act as an α-secretase of amyloid precursor protein, be associated with neurodegeneration diseases, and mediate cell adhesion through non-protease-dependent functions to promote cancer metastasis. ADAM9 is overexpressed in a variety of cancers, such as non-small-cell lung carcinoma, pancreatic cancer, gastric cancer and breast cancer, and is closely related to tumor invasiveness, poor prognosis and drug resistance, based on its key role in tumor initiation, progression and drug resistance.

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Phosphate-buffered solution, pH 7.2-7.4.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay