Species Reactivity      Human

Clone                           H01L02

Source/Isotype           Mouse IgG1, Kappa

Application                 Bioactivity-ELISA

Target                          Detects CDH6

Gene                            CDH6

Other Names              CAD6, KCAD, K-cadherin, Cadherin-6

Gene ID                       1004 (Human)

Background                CDH6, also known as cadherin-6 (K-cadherin, KCAD; CAD6), is a calcium-dependent cell–cell adhesion molecule in the classical cadherin family. It is a transmembrane glycoprotein with an extracellular domain of cadherin repeats, a single-pass transmembrane region, and a cytoplasmic tail that binds catenins to link to the actin cytoskeleton. CDH6 mediates homophilic calcium-dependent adhesion and contributes to tissue morphogenesis, cell sorting, and epithelial integrity. Its expression is tissue- and development-stage dependent, with roles reported in neural, renal, and reproductive tissues, among others.

Besides adhesion, CDH6 participates in signaling through catenin-dependent and cadherin-associated pathways. Its intracellular domain binds β-catenin and p120-catenin, connecting cell adhesion to actin dynamics and potentially modulating Wnt/β-catenin signaling in specific contexts. CDH6 can be regulated via endocytosis and proteolytic cleavage, affecting adhesion strength and signaling cues. Dysregulated CDH6 expression or function has been linked to developmental abnormalities and certain cancers, where it may influence adhesion, migration, and invasiveness.

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay