| Alternative Names | Coagulation Factor III, TF, F3 |
| Source | Cynomolgus Tissue Factor(CD142) Protein; His Tag (GM-88605RP) is expressed from human 293 cells (HEK-293). It contains AA Ser 33 - Glu 252 (Accession # A0A2K5VX02-1). This protein carries a His tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 25.8 KDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | Tissue Factor protein is a transmembrane glycoprotein that belongs to the cytokine receptor superfamily. It is encoded by the F3 gene and is a protein associated with the human hemostatic and immune systems. Tissue Factor protein was initially discovered in blood vessel walls and various extravascular tissues, and later detected on monocytes, macrophages, and tumor cells. Tissue Factor protein regulates the activity of the coagulation cascade by binding to Factor VII/VIIa (FVII/FVIIa) in the blood. FVII/FVIIa is an important serine protease enzyme with the ability to initiate the extrinsic coagulation pathway, leading to thrombin generation and fibrin clot formation, making it a crucial component of the hemostatic system. Research indicates that Tissue Factor protein plays a significant role in regulating blood coagulation, promoting thrombosis, and modulating inflammatory responses. Additionally, the aberrant expression of Tissue Factor protein is associated with tumor progression, angiogenesis, metastasis, and venous thromboembolism (VTE) in cancer patients, making it a potential target for anticoagulant therapy and cancer treatment, including tumor-targeting drug delivery systems and antibody-drug conjugates (ADCs). |
| Alternative Names | Coagulation Factor III, TF, F3 |
| Source | Cynomolgus Tissue Factor(CD142) Protein; His Tag (GM-88605RP) is expressed from human 293 cells (HEK-293). It contains AA Ser 33 - Glu 252 (Accession # A0A2K5VX02-1). This protein carries a His tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 25.8 KDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | Tissue Factor protein is a transmembrane glycoprotein that belongs to the cytokine receptor superfamily. It is encoded by the F3 gene and is a protein associated with the human hemostatic and immune systems. Tissue Factor protein was initially discovered in blood vessel walls and various extravascular tissues, and later detected on monocytes, macrophages, and tumor cells. Tissue Factor protein regulates the activity of the coagulation cascade by binding to Factor VII/VIIa (FVII/FVIIa) in the blood. FVII/FVIIa is an important serine protease enzyme with the ability to initiate the extrinsic coagulation pathway, leading to thrombin generation and fibrin clot formation, making it a crucial component of the hemostatic system. Research indicates that Tissue Factor protein plays a significant role in regulating blood coagulation, promoting thrombosis, and modulating inflammatory responses. Additionally, the aberrant expression of Tissue Factor protein is associated with tumor progression, angiogenesis, metastasis, and venous thromboembolism (VTE) in cancer patients, making it a potential target for anticoagulant therapy and cancer treatment, including tumor-targeting drug delivery systems and antibody-drug conjugates (ADCs). |
