| Alternative Names | Glucagon R, GCGR, Glucagon receptor |
| Source | Human GCGR(26-136) Protein; His Tag (GM-88497RP) is expressed from human 293 cells (HEK-293). It contains AA Ala 26 - Lys 136 (Accession # P47871-1). This protein carries a His tag at the C-terminus. |
| Purity | > 90% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 13.9 KDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | GCGR (glucagon receptor) is a liver-enriched G protein–coupled receptor (GPCR) whose primary ligand is glucagon. When glucagon binds to GCGR, the receptor activates the Gs signaling pathway, coupling receptor activation to downstream metabolic regulation. This makes GCGR an important molecular target in maintaining glucose homeostasis and in diseases such as diabetes. In the signaling pathway, Gs stimulates adenylyl cyclase (AC), leading to increased intracellular cAMP. Elevated cAMP activates protein kinase A (PKA), which phosphorylates key regulators and promotes transcriptional programs that enhance gluconeogenesis and glycogen breakdown in the liver. These events ultimately increase glucose output, and the GCGR/cAMP–PKA axis may also interface with transcription factors such as CREB and other signaling networks to fine-tune the metabolic response. |
| Alternative Names | Glucagon R, GCGR, Glucagon receptor |
| Source | Human GCGR(26-136) Protein; His Tag (GM-88497RP) is expressed from human 293 cells (HEK-293). It contains AA Ala 26 - Lys 136 (Accession # P47871-1). This protein carries a His tag at the C-terminus. |
| Purity | > 90% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 13.9 KDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | GCGR (glucagon receptor) is a liver-enriched G protein–coupled receptor (GPCR) whose primary ligand is glucagon. When glucagon binds to GCGR, the receptor activates the Gs signaling pathway, coupling receptor activation to downstream metabolic regulation. This makes GCGR an important molecular target in maintaining glucose homeostasis and in diseases such as diabetes. In the signaling pathway, Gs stimulates adenylyl cyclase (AC), leading to increased intracellular cAMP. Elevated cAMP activates protein kinase A (PKA), which phosphorylates key regulators and promotes transcriptional programs that enhance gluconeogenesis and glycogen breakdown in the liver. These events ultimately increase glucose output, and the GCGR/cAMP–PKA axis may also interface with transcription factors such as CREB and other signaling networks to fine-tune the metabolic response. |
