| Species Reactivity | Human |
| Clone | Xmab-A2(N67Q) |
| Source/Isotype | Human IgG1, Kappa |
| Application | / |
| Specificity | Detects STEAP1 |
| Gene | STEAP1 |
| Other Names | PRSS24, STEAP |
| Gene ID | 26872 (human) |
| Background | The STEAP1 gene encodes a six-step transmembrane protein belonging to the prostate transmembrane epithelial antigen family, which was originally identified in prostate cancer. This gene is located on the short arm of human chromosome 7, and its product consists of 339 amino acids with unique structural features: it lacks the n-terminal NADPH oxidoreductase domain, but contains a heme cofactor at the c-terminal. STEAP1 is highly expressed in prostate cancer, bladder cancer, lung cancer and other solid tumors, especially in metastatic tumors, while the expression is low in normal tissues, this makes it an ideal target for tumor diagnosis and treatment. At present, antibody drug conjugates and CAR-T cell therapy targeting STEAP1 are under development, showing good anti-tumor potential. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
| Species Reactivity | Human |
| Clone | Xmab-A2(N67Q) |
| Source/Isotype | Human IgG1, Kappa |
| Application | / |
| Specificity | Detects STEAP1 |
| Gene | STEAP1 |
| Other Names | PRSS24, STEAP |
| Gene ID | 26872 (human) |
| Background | The STEAP1 gene encodes a six-step transmembrane protein belonging to the prostate transmembrane epithelial antigen family, which was originally identified in prostate cancer. This gene is located on the short arm of human chromosome 7, and its product consists of 339 amino acids with unique structural features: it lacks the n-terminal NADPH oxidoreductase domain, but contains a heme cofactor at the c-terminal. STEAP1 is highly expressed in prostate cancer, bladder cancer, lung cancer and other solid tumors, especially in metastatic tumors, while the expression is low in normal tissues, this makes it an ideal target for tumor diagnosis and treatment. At present, antibody drug conjugates and CAR-T cell therapy targeting STEAP1 are under development, showing good anti-tumor potential. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
