| Species Reactivity | Human |
| Clone | h11G2 |
| Source/Isotype | Human IgG1, Kappa |
| Application | / |
| Specificity | Detects CXCR5 |
| Gene | CXCR5 |
| Other Names | BLR1, CD185, MDR15 |
| Gene ID | 643 (human) |
| Background | CXCR5 is a member of the CXC chemokine receptor family, which belongs to the G protein-coupled receptor and has a seven-time transmembrane domain. It specifically binds to the chemokine CXCL13, mediates directional migration of B lymphocytes and follicular helper T cells to secondary lymphoid organs, and participates in lymph node development and lymphocyte homing. CXCR5 plays a key role in the construction of immune microenvironment, and its abnormal expression is closely related to autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis, as well as tumor metastasis such as breast cancer and prostate cancer. In recent years, CXCR5 has also made breakthroughs in the fields of pain regulation and sepsis treatment, and has become a new target for immunotherapy and precision medicine. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Supplied as a 0.2 μm filtered solution of 200 mM NaCl in PBS, pH 7.2–7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
| Species Reactivity | Human |
| Clone | h11G2 |
| Source/Isotype | Human IgG1, Kappa |
| Application | / |
| Specificity | Detects CXCR5 |
| Gene | CXCR5 |
| Other Names | BLR1, CD185, MDR15 |
| Gene ID | 643 (human) |
| Background | CXCR5 is a member of the CXC chemokine receptor family, which belongs to the G protein-coupled receptor and has a seven-time transmembrane domain. It specifically binds to the chemokine CXCL13, mediates directional migration of B lymphocytes and follicular helper T cells to secondary lymphoid organs, and participates in lymph node development and lymphocyte homing. CXCR5 plays a key role in the construction of immune microenvironment, and its abnormal expression is closely related to autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis, as well as tumor metastasis such as breast cancer and prostate cancer. In recent years, CXCR5 has also made breakthroughs in the fields of pain regulation and sepsis treatment, and has become a new target for immunotherapy and precision medicine. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Supplied as a 0.2 μm filtered solution of 200 mM NaCl in PBS, pH 7.2–7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
