| Alternative Names | GUCY2C, GUC2C, STAR, STA receptor, hSTAR, GC-C |
| Source | Human GUCY2C Protein; His Tag (GM-88562RP) is expressed from human 293 cells (HEK-293). It contains AA Ser 24 - Gln 430 (Accession # P25092-1). This protein carries a his tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 46.8 KDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | GUCY2C protein, the full name of which is Guanylate Cyclase 2C, is a transmembrane receptor guanylate cyclase that functions as a key regulator of intestinal epithelial homeostasis. The GUCY2C protein is encoded by the GUCY2C gene and is activated by endogenous peptide ligands such as guanylin and uroguanylin, as well as by certain bacterial enterotoxins. Upon activation, GUCY2C converts GTP to cyclic GMP (cGMP), thereby regulating ion transport, fluid secretion, cell proliferation, and differentiation in the intestinal epithelium. GUCY2C protein plays an important role in gastrointestinal diseases and various cancers, especially colorectal cancer. It is highly and selectively expressed on the apical surface of intestinal epithelial cells and is frequently retained or overexpressed in colorectal and some gastric cancers, while showing limited expression in most normal extra-intestinal tissues. Therefore, GUCY2C is considered an attractive target for cancer diagnosis and treatment, including vaccines, antibody-drug conjugates, and other targeted therapies. Overall, GUCY2C protein is an important signaling receptor with significant potential in the research and treatment of colorectal and other gastrointestinal cancers. |
| Alternative Names | GUCY2C, GUC2C, STAR, STA receptor, hSTAR, GC-C |
| Source | Human GUCY2C Protein; His Tag (GM-88562RP) is expressed from human 293 cells (HEK-293). It contains AA Ser 24 - Gln 430 (Accession # P25092-1). This protein carries a his tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 46.8 KDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | GUCY2C protein, the full name of which is Guanylate Cyclase 2C, is a transmembrane receptor guanylate cyclase that functions as a key regulator of intestinal epithelial homeostasis. The GUCY2C protein is encoded by the GUCY2C gene and is activated by endogenous peptide ligands such as guanylin and uroguanylin, as well as by certain bacterial enterotoxins. Upon activation, GUCY2C converts GTP to cyclic GMP (cGMP), thereby regulating ion transport, fluid secretion, cell proliferation, and differentiation in the intestinal epithelium. GUCY2C protein plays an important role in gastrointestinal diseases and various cancers, especially colorectal cancer. It is highly and selectively expressed on the apical surface of intestinal epithelial cells and is frequently retained or overexpressed in colorectal and some gastric cancers, while showing limited expression in most normal extra-intestinal tissues. Therefore, GUCY2C is considered an attractive target for cancer diagnosis and treatment, including vaccines, antibody-drug conjugates, and other targeted therapies. Overall, GUCY2C protein is an important signaling receptor with significant potential in the research and treatment of colorectal and other gastrointestinal cancers. |
