| Alternative Names | FAPalpha, SIMP, Seprase, APCE |
| Source | Cynomolgus FAP Protein; His Tag (GM-88618RP) is expressed from human 293 cells (HEK-293). It contains AA Leu 26 - Asp 760 (Accession # XP_005573377.1). This protein carries a His tag at the N-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 85.9 KDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | FAP protein (Fibroblast Activation Protein) is a transmembrane serine protease that belongs to the dipeptidyl peptidase (DPP) family. It is encoded by the FAP gene and is a protein associated with the human tumor microenvironment and immune system. FAP protein was initially discovered on cancer-associated fibroblasts (CAFs) in solid tumors and later detected on activated fibroblasts in wound healing, chronic inflammation, and certain sarcoma cells. FAP protein regulates the activity of tumor-associated fibroblasts and immune cells by binding to its substrates, including collagen, gelatin, fibroblast growth factor (FGF), and the cytokine stromal cell-derived factor-1 (SDF-1/CXCL12). Cancer-associated fibroblasts are an important type of stromal cell with the ability to remodel the extracellular matrix, promote tumor growth, and suppress anti-tumor immune responses, making them crucial members of the tumor microenvironment. Research indicates that FAP protein plays a significant role in regulating fibroblast activity, promoting tumor progression, and modulating immune suppression. Additionally, the expression of FAP protein is associated with tumor development, invasion, and poor prognosis, making it a potential target for immunotherapy, including FAP-targeted CAR-T cells, antibody-drug conjugates (ADCs), and small molecule inhibitors for cancer treatment. |
| Alternative Names | FAPalpha, SIMP, Seprase, APCE |
| Source | Cynomolgus FAP Protein; His Tag (GM-88618RP) is expressed from human 293 cells (HEK-293). It contains AA Leu 26 - Asp 760 (Accession # XP_005573377.1). This protein carries a His tag at the N-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 85.9 KDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | FAP protein (Fibroblast Activation Protein) is a transmembrane serine protease that belongs to the dipeptidyl peptidase (DPP) family. It is encoded by the FAP gene and is a protein associated with the human tumor microenvironment and immune system. FAP protein was initially discovered on cancer-associated fibroblasts (CAFs) in solid tumors and later detected on activated fibroblasts in wound healing, chronic inflammation, and certain sarcoma cells. FAP protein regulates the activity of tumor-associated fibroblasts and immune cells by binding to its substrates, including collagen, gelatin, fibroblast growth factor (FGF), and the cytokine stromal cell-derived factor-1 (SDF-1/CXCL12). Cancer-associated fibroblasts are an important type of stromal cell with the ability to remodel the extracellular matrix, promote tumor growth, and suppress anti-tumor immune responses, making them crucial members of the tumor microenvironment. Research indicates that FAP protein plays a significant role in regulating fibroblast activity, promoting tumor progression, and modulating immune suppression. Additionally, the expression of FAP protein is associated with tumor development, invasion, and poor prognosis, making it a potential target for immunotherapy, including FAP-targeted CAR-T cells, antibody-drug conjugates (ADCs), and small molecule inhibitors for cancer treatment. |
