| Alternative Names | Delta4 |
| Source | Human DLL4 Protein; His Tag (GM-88575RP) is expressed from human 293 cells (HEK-293). It contains AA Ser 27 - Pro 524 (Accession # Q9NR61-1). This protein carries a His tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 55.1 KDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | DLL4 protein is a transmembrane ligand that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. It is encoded by the DLL4 gene and is a critical regulator of cell fate determination, angiogenesis, and vascular development. DLL4 protein is primarily expressed in the vascular endothelium and plays a non-redundant role in arterial specification and sprouting angiogenesis during embryonic development. DLL4 protein regulates the activity of endothelial cells and other cell types by binding to the Notch1 and Notch4 receptors on adjacent cells. The DLL4/Notch signaling pathway is essential for coordinating cell differentiation, proliferation, and migration, making it a key mediator of vascular patterning and homeostasis. Research indicates that DLL4 protein plays a significant role in pathological angiogenesis, particularly in tumor growth and progression. Its expression is often upregulated in the tumor vasculature, where it promotes non-productive, dysfunctional blood vessel formation. This mechanism contributes to tumor immune evasion and resistance to anti-angiogenic therapies, positioning DLL4 as a promising therapeutic target for cancer treatment, either alone or in combination with other immunotherapies. |
| Alternative Names | Delta4 |
| Source | Human DLL4 Protein; His Tag (GM-88575RP) is expressed from human 293 cells (HEK-293). It contains AA Ser 27 - Pro 524 (Accession # Q9NR61-1). This protein carries a His tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 55.1 KDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | DLL4 protein is a transmembrane ligand that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. It is encoded by the DLL4 gene and is a critical regulator of cell fate determination, angiogenesis, and vascular development. DLL4 protein is primarily expressed in the vascular endothelium and plays a non-redundant role in arterial specification and sprouting angiogenesis during embryonic development. DLL4 protein regulates the activity of endothelial cells and other cell types by binding to the Notch1 and Notch4 receptors on adjacent cells. The DLL4/Notch signaling pathway is essential for coordinating cell differentiation, proliferation, and migration, making it a key mediator of vascular patterning and homeostasis. Research indicates that DLL4 protein plays a significant role in pathological angiogenesis, particularly in tumor growth and progression. Its expression is often upregulated in the tumor vasculature, where it promotes non-productive, dysfunctional blood vessel formation. This mechanism contributes to tumor immune evasion and resistance to anti-angiogenic therapies, positioning DLL4 as a promising therapeutic target for cancer treatment, either alone or in combination with other immunotherapies. |
