| Alternative Names | 4Ig-B7-H3, B7-H3, PSEC0249, UNQ309, PRO352, B7 homolog 3 |
| Source | Cynomolgus CD276(B7H3 4Ig) Protein; His Tag (GM-88536RP) is expressed from human 293 cells (HEK-293). It contains AA Leu 29 - Glu 465 (Accession # XP_015308534.1). This protein carries a His tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 47.9 KDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | B7H3, also known as CD276, is a protein belonging to the B7 family of immune regulatory molecules. It is a transmembrane protein that plays a significant role in immune regulation and tumor immunotherapy. B7H3 can exist in different structural forms, with variations such as 4IG (containing 4 immunoglobulin domains) and 2IG (containing 2 immunoglobulin domains). This protein is known to be highly expressed in various tumors and is closely associated with tumor development, progression, and prognosis. In the context of tumor immunotherapy, B7H3 serves as an important target due to its ability to modulate T cell responses. Inhibiting B7H3 protein can enhance the killing capacity of T cells against tumor cells, thereby improving the effectiveness of cancer treatment. Overall, B7H3 plays a crucial role in immune regulation, immune response modulation, and tumor immune evasion. Understanding the mechanisms involving B7H3 protein can provide valuable insights into immunotherapy strategies and tumor development. |
| Alternative Names | 4Ig-B7-H3, B7-H3, PSEC0249, UNQ309, PRO352, B7 homolog 3 |
| Source | Cynomolgus CD276(B7H3 4Ig) Protein; His Tag (GM-88536RP) is expressed from human 293 cells (HEK-293). It contains AA Leu 29 - Glu 465 (Accession # XP_015308534.1). This protein carries a His tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 47.9 KDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | B7H3, also known as CD276, is a protein belonging to the B7 family of immune regulatory molecules. It is a transmembrane protein that plays a significant role in immune regulation and tumor immunotherapy. B7H3 can exist in different structural forms, with variations such as 4IG (containing 4 immunoglobulin domains) and 2IG (containing 2 immunoglobulin domains). This protein is known to be highly expressed in various tumors and is closely associated with tumor development, progression, and prognosis. In the context of tumor immunotherapy, B7H3 serves as an important target due to its ability to modulate T cell responses. Inhibiting B7H3 protein can enhance the killing capacity of T cells against tumor cells, thereby improving the effectiveness of cancer treatment. Overall, B7H3 plays a crucial role in immune regulation, immune response modulation, and tumor immune evasion. Understanding the mechanisms involving B7H3 protein can provide valuable insights into immunotherapy strategies and tumor development. |
