| Alternative Names | IgG1 Fc |
| Source | Human IgG1 Fc Protein; His Tag (GM-88587RP) is expressed from human 293 cells (HEK-293). It contains AA Pro 100 - Lys 330 (Accession # P01857-1). This protein carries a His tag at the N-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 26.8 KDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | IgG1 Fc protein is a functional fragment of immunoglobulin G1 (IgG1), which belongs to the antibody superfamily. It is encoded by the constant region of the IGHG1 gene and is a protein associated with the human immune system. IgG1 Fc protein is derived from the constant region of the IgG1 heavy chain and is widely expressed in plasma and lymphoid tissues. IgG1 Fc protein regulates the activity of various immune cells, including natural killer (NK) cells, macrophages, and dendritic cells, by binding to Fc gamma receptors (FcγRs) on the surface of these cells. FcγR-expressing immune cells are important effectors of the immune system, with the ability to mediate antibody-dependent cellular cytotoxicity (ADCC), phagocytosis, and cytokine release, making them crucial members of the immune system. Research indicates that IgG1 Fc protein plays a significant role in regulating immune cell activity, promoting cytotoxicity against targeted cells, and modulating inflammatory responses. Additionally, the engineered forms of IgG1 Fc protein have been developed to enhance or reduce immune effector functions, making it a potential therapeutic target and platform for antibody-based immunotherapies, including the treatment of cancer, autoimmune diseases, and inflammatory disorders. |
| Alternative Names | IgG1 Fc |
| Source | Human IgG1 Fc Protein; His Tag (GM-88587RP) is expressed from human 293 cells (HEK-293). It contains AA Pro 100 - Lys 330 (Accession # P01857-1). This protein carries a His tag at the N-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 26.8 KDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | IgG1 Fc protein is a functional fragment of immunoglobulin G1 (IgG1), which belongs to the antibody superfamily. It is encoded by the constant region of the IGHG1 gene and is a protein associated with the human immune system. IgG1 Fc protein is derived from the constant region of the IgG1 heavy chain and is widely expressed in plasma and lymphoid tissues. IgG1 Fc protein regulates the activity of various immune cells, including natural killer (NK) cells, macrophages, and dendritic cells, by binding to Fc gamma receptors (FcγRs) on the surface of these cells. FcγR-expressing immune cells are important effectors of the immune system, with the ability to mediate antibody-dependent cellular cytotoxicity (ADCC), phagocytosis, and cytokine release, making them crucial members of the immune system. Research indicates that IgG1 Fc protein plays a significant role in regulating immune cell activity, promoting cytotoxicity against targeted cells, and modulating inflammatory responses. Additionally, the engineered forms of IgG1 Fc protein have been developed to enhance or reduce immune effector functions, making it a potential therapeutic target and platform for antibody-based immunotherapies, including the treatment of cancer, autoimmune diseases, and inflammatory disorders. |
