| GIPR (Glucose-dependent Insulinotropic Polypeptide Receptor) is a G protein-coupled receptor encoded by the GIPR gene, mainly expressed in pancreatic islets, gastrointestinal tract, adipose tissue, and the central nervous system. It plays a key role in glucose metabolism and energy homeostasis by stimulating insulin secretion and promoting nutrient uptake, and is closely associated with type 2 diabetes and obesity. Upon GIP binding, GIPR activates Gs protein to increase cAMP levels, thereby enhancing insulin secretion, and recruits β-arrestin to mediate receptor desensitization, internalization, and additional metabolic responses. Thus, GIPR is a critical regulator of glucose homeostasis and a promising therapeutic target for metabolic diseases. H_GIPR β-Arrestin2 Reporter CHO-K1 Cell Line is a clonal stable CHO-K1 cell line constructed using lentiviral technology, constitutive expression of the GIPR gene, and detected using luciferase reporter technology. When the ligand binds to GIPR, it recruits β-arrestin2 fused with a downstream luciferase reporter gene. Upon addition of the luciferase substrate, the enzyme catalyzes the substrate reaction, producing a detectable luminescent signal. Therefore, this system can be used to evaluate the in vitro efficacy of related drugs. |
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| GIPR (Glucose-dependent Insulinotropic Polypeptide Receptor) is a G protein-coupled receptor encoded by the GIPR gene, mainly expressed in pancreatic islets, gastrointestinal tract, adipose tissue, and the central nervous system. It plays a key role in glucose metabolism and energy homeostasis by stimulating insulin secretion and promoting nutrient uptake, and is closely associated with type 2 diabetes and obesity. Upon GIP binding, GIPR activates Gs protein to increase cAMP levels, thereby enhancing insulin secretion, and recruits β-arrestin to mediate receptor desensitization, internalization, and additional metabolic responses. Thus, GIPR is a critical regulator of glucose homeostasis and a promising therapeutic target for metabolic diseases. H_GIPR β-Arrestin2 Reporter CHO-K1 Cell Line is a clonal stable CHO-K1 cell line constructed using lentiviral technology, constitutive expression of the GIPR gene, and detected using luciferase reporter technology. When the ligand binds to GIPR, it recruits β-arrestin2 fused with a downstream luciferase reporter gene. Upon addition of the luciferase substrate, the enzyme catalyzes the substrate reaction, producing a detectable luminescent signal. Therefore, this system can be used to evaluate the in vitro efficacy of related drugs. |
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